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The purpose of this systematic review was to compare corticosteroid injections with non-steroidal anti-inflammatory drug (NSAID) injections for musculoskeletal pain. This may not be of interest if the outcome is not pain reduction or symptomatic recovery. This systematic review and meta-analysis included randomized trials, observational and non-randomized case series trials, controlled trials and quasi-controlled trials. Only trials that did not use an analgesic agent, corticosteroid or NSAIDs were included in the review. The objective of the search was to systematically review articles published from 1966 to 2008 and to search bibliographies of relevant publications. Searches for 'medicine-based pain' and 'painkillers' were applied. To be included in the review, a minimum of 5 trials in adults and 2 in children with chronic low back pain (i.e. pain after any surgical procedure) had to be reported. We limited our search to systematic reviews and meta-analyses, and excluded random controlled trials. The search was completed on December 2008. No language was specified except English. A total of 918 articles on 'painkillers' and 'corticosteroids' were identified. In 2006, the International Society for the Study of Pain endorsed a policy of avoiding using drugs other than NSAIDs for low back pain (1). Several meta-analyses have suggested that treatment of chronic low back pain may benefit from corticosteroids, but the results were inconclusive. A systematic review of randomized trials by Smith and colleagues showed that NSAIDs did not reduce pain (2). A systematic review of randomised controlled trials showed that corticosteroids did not reduce neuropathic pain, and a meta-analysis of randomised controlled trials showed no clinical benefit of corticosteroid use (3, 4). However, this was not a sufficient evidence base to justify prescribing NSAIDs as first-line treatment. A systematic review by van der Hoeven et al. (5) suggested that corticosteroid use may be associated with adverse neurophysiological effects, especially on cognitive function. In that paper, a meta-analysis of 9 trials compared corticosteroids (1 week) with placebo and a combination of placebo, acetaminophen (10 mg), acyclovir cream (12.2% solution) and metoprolol (0.35 mg) cream. There was a significant reduction in pain (mean difference −8.0 points). We conducted a systematic review on 'corticosteroids and low back pain'. However, there were some differences between our search strategy and that of van der Hoe Related Article:
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