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In bodybuilding, Nolvadex (Tamoxifen Citrate) is used as both an anabolic steroid cycle ancillary drug and as recovery or as a post anabolic steroid cycle therapy drug(such as post cycle growth hormone injections) with the primary mode of action being to upregulate testosterone synthesis in muscle (via aromatase inhibition) with subsequent growth-hormone release, primarily via its action in the pituitary gland. It works by inhibiting aromatase in the tissue that produces estrogens (which make women fertile on steroids). Nolvadex itself, is metabolized by aromatase to estrogen in the liver via the FTO enzyme and then to the active metabolite dihydrotestosterone (DHT). The liver converts these steroid hormones to DHT during the course of a steroid cycle. Because DHT is a potent inhibitor of androgen receptors in the body, Nolvadex is an anabolic steroid with a similar potency and side-effects profile to testosterone. Because DHT is also found in our bodies. in greater quantity than testosterone, DHT is an extremely potent non-androgenic anabolic steroid. It was first developed during steroid research. The first reference source came out at 1986 when Professor James F. Martin, director of the American Chemistry Council's International Research and Development (IRD) Center in Virginia, published an article in the Journal of Clinical Anesthetics and a review of the literature conducted in that year. In 1987, a large volume of research came from Richard H. Friedman, Ph.D, of the National Center for State Drug Control Policy in Ohio, who showed that DHT is a potent non-androgenic anabolic steroid, and demonstrated the ability of DHT to induce significant changes in body composition and bone density in women and the development of a non-mammary tumor in lab animals. The review by the International Research and Development Center's Friedman concluded that there is no evidence that DHT is a female sex hormone and that it is safe to add to a woman's health regimen with the exception that it may cause gynecomastia (increased breast size). The review by Friedman also showed that DHT can be a precursor to the human testes (male sexual functions). Nolvadex had been around in Europe since 1990. By 1995 the US had the first report of a woman taking DHEA (17) to induce fertility after using Nolvadex. [18] The first DHT-induced woman case to result in an investigation was reported from California. [19] In the first UK case, the authors reported an 18 month follow-up of 4 women who discontinued androgen injections Similar articles:
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